Practice MCAT Question - Q100 - Answer!
Which sequence of depolarization best describes the order in which a muscle contracts?
A. Sarcoplasmic reticulum, t-tubules, sarcolemma
B. Sarcoplasmic reticulum, sarcolemma, t-tubules
C. Sarcolemma, t-tubules, sarcoplasmic reticulum
D. Sarcolemma, sarcoplasmic reticulum, t-tubules
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The correct answer is (C). When acetylcholine is released from the motor neuron to the neuromuscular junction, the sarcolemma depolarizes. Depolarization then spreads along the outside, through the t-tubules to the inside, and finally to the sarcoplasmic reticulum, where calcium ions are released.
